Are Polynucleotides Effective for the Under-Eye Area?

Polynucleotides are purified DNA fragments, usually sourced from salmon or trout sperm, and are highly biocompatible with human tissue. Once injected, they stimulate fibroblasts, boost collagen and elastin production, and enhance microcirculation. This regenerative action makes them particularly effective for the thin, fragile skin under the eyes, where subtle changes create visible improvements.

•  • Stimulates Collagen and Elastin
  Supports firmer, smoother skin by reducing fine lines, wrinkles, and crepiness.
•  • Improves Texture and Hydration
  Enhances moisture retention and hyaluronic acid production, leaving the under-eye area plumper and more refreshed.
•  • Reduces Dark Circles
  Thickens skin, improves circulation, and calms inflammation. Their antioxidant properties also help minimize pigmentation and oxidative stress.
•  • Promotes Long-Term Skin Health
  Encourages tissue repair and regeneration, making treatments valuable for both correction and prevention.
•  • Provides Natural-Looking Results
  Unlike fillers, which can occasionally look overdone, PNs subtly enhance skin quality without adding obvious volume.

When performed by a qualified practitioner, polynucleotide injections are generally safe. However, patients should be aware of the following:

•  • Common, temporary effects: mild redness, swelling, bruising, or small bumps that usually fade within days.
•  • Rare complications: prolonged swelling, infection, or nodules, typically linked to poor technique—highlighting the importance of choosing an experienced injector.
•  • Allergy risks: because PNs are fish-derived, they are not suitable for individuals with fish allergies.

•  • Gradual improvements: results appear over weeks to months as the skin regenerates.
•  • Course of sessions: typically 2–4 treatments spaced 2–4 weeks apart, with maintenance every 6–12 months.
•  • Not a filler substitute: for deep tear troughs or significant hollowing, PNs may be combined with dermal fillers for more comprehensive rejuvenation.
•  • Individual variation: age, skin type, and lifestyle all influence results.

PNs are best suited for those seeking subtle, natural improvements—such as addressing early aging, mild hollowing, or dark circles. They are less effective for severe volume loss, where fillers or surgical options may be more appropriate. A professional consultation ensures the right treatment plan.

•  • Procedure: a 20–30 minute session with fine-needle or cannula injections, often preceded by numbing cream.
•  • Downtime: minimal, with swelling or bruising resolving in a few days. Makeup can usually be worn the next day.
•  • Aftercare: avoid intense exercise, heat (saunas, steam rooms), and alcohol for 24–48 hours. Follow tailored instructions from your practitioner.

•  • Dermal Fillers: offer immediate volume; PNs improve long-term skin quality. A combination can deliver balanced results.
•  • PRP (Platelet-Rich Plasma): both stimulate regeneration, but PNs provide a standardized, consistent formulation, while PRP results vary with blood quality.
•  • Laser or Microneedling: address surface concerns, whereas PNs work deeper to stimulate cellular repair.

Polynucleotides provide a natural, regenerative solution for under-eye rejuvenation—improving hydration, reducing dark circles, and enhancing overall skin quality without altering facial volume. While not a universal fix, they can be a powerful addition to a personalized aesthetic plan, especially when paired with complementary treatments.

To find out if polynucleotides are right for you, consult a qualified aesthetic professional who can tailor recommendations to your goals and medical history.