Botox vs Polynucleotides: Which Is Better for Wrinkles and Anti-Aging?

Botox (botulinum toxin type A) is a neuromodulator that temporarily relaxes facial muscles responsible for dynamic wrinkles — the lines that appear when you make expressions.

Commonly Treated Areas:

•  • Forehead lines (horizontal)
•  • Frown lines (between eyebrows)
•  • Crow’s feet (around eyes)
•  • Bunny lines (nose)
•  • Neck bands (platysmal cords)

How Long Do Results Last?

•  • 3 to 6 months
•  • Repeat treatments maintain and can even prolong results over time

How It Works:

Botox blocks nerve signals to overactive muscles. When the muscle relaxes:

•  • Wrinkles soften or disappear
•  • Skin surface becomes smoother
•  • New wrinkles are prevented

It’s preventative medicine as much as it is cosmetic.

Fun fact: Regular Botox can delay the formation of permanent (static) wrinkles by stopping repetitive movement.

Polynucleotides (PN) are purified DNA fragments — typically derived from salmon — that stimulate the skin’s natural repair mechanisms. Often called the “salmon DNA facial”, this treatment works at a cellular level to rejuvenate ageing or damaged skin.

Commonly Treated Concerns:

•  • Fine lines and crepiness
•  • Dull, dehydrated skin
•  • Sun damage and pigmentation
•  • Thin, fragile skin (especially under eyes)
•  • Post-procedure recovery (after lasers, peels, microneedling)

How Long Do Results Last?

•  • 6 to 12 months, with optimal results after 2–3 sessions, spaced 2–4 weeks apart
•  • Maintenance every 6–12 months

How It Works:

Once injected, polynucleotides:

•  • Activate fibroblasts — the cells that produce collagen and elastin
•  • Boost hyaluronic acid synthesis for deep hydration
•  • Reduce inflammation and oxidative stress
•  • Improve microcirculation and tissue repair

Result? Thicker, stronger, more resilient skin — not just a temporary fix.

Think of PN as a “skin reboot” — it doesn’t stop movement, but it repairs the damage caused by years of it.

Let’s match your concerns to the right solution.

Choose Botox If:

•  • You have visible forehead lines, frown lines, or crow’s feet
•  • Your wrinkles appear only when you move
•  • You want fast, predictable results
•  • You’re in your late 20s to 50s+ and want to prevent deep wrinkles
•  • You’re preparing for an event and need quick smoothing

Ideal for: Expression lines, prevention, muscle relaxation.

Choose Polynucleotides If:

•  • Your skin looks dull, tired, or thin
•  • You have fine lines at rest (static wrinkles)
•  • You want long-term skin health, not just a quick fix
•  • You’re recovering from sun damage or procedures
•  • You’re concerned about skin laxity or under-eye hollows
•  • You want natural radiance with zero “frozen” look

Ideal for: Skin rejuvenation, hydration, repair, and resilience.

Absolutely — and it’s one of the most effective anti-ageing strategies available.

Think of it like skincare layers:

•  • Botox = top layer (stops the cause of wrinkles)
•  • Polynucleotides = foundation (repairs the damage)

Together, they deliver:

•  • Smoother skin texture
•  • Reduced wrinkle depth
•  • Healthier, younger-looking skin
•  • Longer-lasting results

Example Treatment Plan:

•  • Session 1: Botox to relax forehead, frown, and eye area
•  • 2–4 weeks later: Polynucleotides to face, neck, or under eyes
•  • Maintenance: Botox every 4–6 months, PN every 6–12 months

This combo is especially popular among:

•  • Preventative patients (30s–40s)
•  • Mature skin patients (50s+) wanting comprehensive rejuvenation
•  • Post-laser or post-peel patients needing repair

Can polynucleotides replace Botox?

No. They don’t affect muscle movement. If you have dynamic wrinkles, Botox is still the best solution.

Can I have both in the same session?

Yes — many patients do. We typically inject Botox first, then PN, using different depths and techniques. Safe and effective.

Will polynucleotides make my face look stiff?

No. Unlike Botox, PN don’t touch muscles. Your face stays expressive, but the skin looks healthier and more radiant.

Which one hurts more?

Both are well-tolerated. Botox uses tiny needles in precise spots. PN use a fan technique with fine needles and numbing cream. Most patients say it’s mild discomfort.

Is one safer than the other?

Both are extremely safe when administered by trained professionals. Botox has a 30+ year safety record. PN are biocompatible, non-allergenic, and integrate naturally.

Pro tip: Use Botox to prevent, and PN to repair — that’s how you age gracefully.

At Oblique House Of Aesthetics in London, we believe in intelligent ageing — using science to enhance your natural beauty.

Whether you’re new to injectables or a seasoned patient, we’ll help you choose the right path.

Book a personalised anti-ageing consultation at Oblique House Of Aesthetics in London.