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Polynucleotides vs. Skin Boosters: Key Differences in Skin Rejuvenation

Polynucleotides vs. Skin Boosters: Key Differences in Skin Rejuvenation

date of publication: 24/09/2025
Reading TIME: 2 min 10 sec
Author of the post: Oblique

Both polynucleotides and skin boosters are injectable treatments designed to rejuvenate the skin, but they work in very different ways and deliver distinct results.

Content

Skin Boosters

Core Component: Non-crosslinked hyaluronic acid (HA).

How They Work:

Often called “injectable moisturizers,” skin boosters deliver hyaluronic acid deep into the skin, where it attracts and holds water. This infusion of hydration smooths, softens, and brightens the skin, leaving it refreshed and glowing.

Results:

• Immediate improvement in hydration, suppleness, and radiance.
• Reduces dryness, fine lines, and dullness.
• Creates a healthy, luminous complexion.

Best For: Younger clients or anyone looking for a quick refresh, especially before events or special occasions.

Polynucleotides

Core Component: Purified DNA fragments, usually derived from salmon or trout.

How They Work:

Polynucleotides act as bio-stimulators, repairing the skin at a cellular level. They activate fibroblasts (which produce collagen and elastin), encourage new blood vessel growth, and protect against oxidative stress—helping the skin heal and regenerate from within.

Results:

• Gradual but long-lasting improvements in firmness, elasticity, and thickness.
• Effective for aging skin, sun damage, scarring, and under-eye rejuvenation.
• Strengthens the skin’s foundation for long-term health.

Best For: Those with visible signs of aging or compromised skin quality who want regenerative, structural repair rather than just surface hydration.

Comparison at a Glance

Feature	Polynucleotides	Skin Boosters
Main Component	Purified DNA fragments (salmon-derived)	Non-crosslinked Hyaluronic Acid
Primary Action	Stimulates cellular repair, collagen and elastin production	Deep hydration through water retention
Primary Goal	Long-term regeneration & structural repair	Immediate hydration & glow
Results Timeline	Gradual (weeks–months), lasting up to 18 months	Rapid (days), lasting ~6 months
Best For	Aging skin, laxity, scars, sun damage	Dry, dull, or fine-line-prone skin
Mechanism	Bio-stimulation – activates fibroblasts for natural regeneration	Hydration – binds water molecules in the skin
Treatment Approach	Corrective – addresses underlying skin structure	Preventive/Maintenance – enhances skin quality
Ideal Candidate Age	30s-50s+ with visible signs of aging	20s-40s looking for maintenance and glow
Downtime	Minimal (slight redness for 24-48 hours)	Very minimal (possible minor swelling)

Can They Be Combined?

Yes. Polynucleotides rebuild and strengthen the skin over time, while skin boosters provide instant hydration and radiance. Used together, they deliver both long-term regeneration and immediate glow for truly comprehensive skin rejuvenation.

Best services for you

30 min

Nithya Collagen Skin Booster

from £285

A groundbreaking age reversing collagen treatment.

Benefits

Safety
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There is nearly no downtime

Oblique

Professional dermatologist at Oblique Beauty House

Date of publication24/09/2025

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